Neuroinflammation is a result of chronic immune system activation, often initiated by gut dysbiosis in autistic children. Dysregulated gut flora produces harmful metabolites that breach the gut barrier, triggering systemic inflammation. This inflammation can then activate microglial cells in the brain, disrupting neuroplasticity and communication between neurons. The presence of activated microglia is associated with impaired learning, memory, and behavioral challenges in autism.Restoring gut health is a vital strategy to reduce brain inflammation. Using anti-inflammatory supplements such as Omega-3 fatty acids, curcumin, and glutathione can help modulate the immune system and reduce inflammation both in the gut and the brain. Supporting the body’s detoxification pathways and working with a practitioner for individualized testing are also crucial steps to manage ongoing inflammation.